Activate the eBook version of this title at no additional charge. Elsevier eBooks for Practicing Clinicians gives you the power to browse and search content, view enhanced images, highlight and take notes—both online and oine. Unlock your eBook today. Scratch box below to reveal your code 3.
Type code into “Enter Code” box 4. Log in or Sign up 6. Go to “My Library” It’s that easy! Place Peel Off Sticker Here For technical assistance: email expertconsult.com call 1-800-401-9962 (inside the US) call +1-314-447-8300 (outside the US) Use of the current edition of the electronic version of this book (eBook) is subject to the terms of the nontransferable, limited license granted on expertconsult. Access to the eBook is limited to the first individual who redeems the PIN, located on the inside cover of this book, at expertconsult.com and may not be transferred to another party by resale, lending, or other means.
2020_PC Miller’s Basics of ANESTHESIA EIGHTH EDITION Miller’s Basics of ANESTHESIA EIGHTH EDITION Manuel C., MD Professor and Vice Chair for Education Department of Anesthesia and Perioperative Care University of California, San Francisco San Francisco, California Elsevier 1600 John F. Ste 1800 Philadelphia, PA 19103-2899 MILLER'S BASICS OF ANESTHESIA, EIGHTH EDITION ISBN: 978-0-323796774 Copyright © 2023 by Elsevier Inc. All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic ormechanical, including photocopying, recording, or any information storage and retrieval system, without permission in writing from the publisher.
Details on how to seek permission, further information about the Publisher's permissions policies and our arrangements with organizations such asthe Copyright Clearance Center and the Copyright Licensing Agency, can be found at our website: www.com/permissions This book and the individual contributions contained in it are protected under copyright by the Publisher (other than as may be noted herein). Notice Practitioners and researchers must always rely on their own experience and knowledge in evaluat- ing and using any information, methods, compounds or experiments described herein.Because of rapid advances in the medical sciences, in particular, independent verification of diagnoses and drug dosages should be made. To the fullest extent of the law, no responsibility is assumed by Elsevier, authors, editors or contributors for any injury and/or damage to persons or property as a matter of products liability, negligence or otherwise, or from any use or operation of any methods, products, instructions, or ideas contained in the material herein. Previous editions copyrighted 2018, 2011, 2007, 2000, 1994, 1989, 1984.
Content Strategist: Kayla Wolfe Content Development Specialist: Ann R. Anderson Publishing Services Manager: Shereen Jameel Project Manager: Beula Christopher Design Direction: Ryan Cook Printed in India. Last digit is the print number: 9 8 7 6 5 4 3 2 1 To my wife, Susan, and daughter, Allison, for their support and encouragement while I was working on this book throughout the pandemic; to Dr. Miller for his mentorship, especially regarding textbooks; and to all students of this wondrous specialty of anesthesiology.
Abdelmalak, MD, FASA, SAMBA-F Charles B. Berde, MD, PhD Professor of Anesthesiology Senior Associate in Perioperative Anesthesia Departments of General Anesthesiology and Outcomes Research Department of Anesthesiology, Critical Care, and Pain Medicine Anesthesiology Institute Boston Children's Hospital; Cleveland Clinic Professor of Anesthesia and Pediatrics Cleveland, Ohio Harvard Medical School Boston, Massachusetts Christopher R. Abrecht, MD Assistant Professor Laura Berenstain, MD, FASA Department of Anesthesia and Perioperative Care Adjunct Professor of Clinical Anesthesiology Division of Pain Medicine University of Cincinnati College of Medicine; University of California, San Francisco Division of Pediatric Cardiac Anesthesia San Francisco, California Cincinnati Children's Hospital Medical Center Cincinnati, Ohio Meredith C. Adams, MD, MS Assistant Professor Jeanna D.
Blitz, MD Department of Anesthesiology Associate Professor of Anesthesiology Wake Forest Baptist Health Duke University School of Medicine; Winston-Salem, North Carolina Department of Anesthesiology Duke University Medical Center Ashish Agrawal, MD Durham, North Carolina Assistant Professor Department of Anesthesia and Perioperative Care University of California, San Francisco Michael P. Bokoch, MD, PhD San Francisco, California Assistant Professor Department of Anesthesia and Perioperative Care Dean B. Andropoulos, MD, MHCM University of California, San Francisco Anesthesiologist-in-Chief San Francisco, California Anesthesiology, Perioperative and Pain Medicine Texas Children's Hospital; Emilee Borgmeier, MD Professor and Vice Chair for Clinical Affairs Assistant Professor of Anesthesiology Anesthesiology Department of Anesthesiology Baylor College of Medicine University of Utah Houston, Texas Salt Lake City, Utah vii Contributors Joanna Bouez, MD Catherine Chiu, MD Clinical Fellow Fellow Department of Anesthesiology Department of Anesthesia and Perioperative Care Toronto Western Hospital, University Health Network University of California, San Francisco University of Toronto San Francisco, California Toronto, Ontario, Canada Matthias R. Braehler, MD, PhD Frances Chung, MBBS, FRCPC Professor Professor Department of Anesthesia and Perioperative Care Department of Anesthesiology University of California, San Francisco Toronto Western Hospital, University Health Network San Francisco, California University of Toronto Toronto, Ontario, Canada Kristine E.
Breyer, MD Associate Professor Hemra Cil, MD Department of Anesthesia and Perioperative Care Assistant Professor University of California, San Francisco Department of Anesthesia and Perioperative Care San Francisco, California University of California, San Francisco San Francisco, California Richard Brull, MD, FRCPC Professor Department of Anesthesia Neal H. Cohen, MD, MPH, MS University of Toronto; Professor Emeritus Evelyn Bateman Cara Operations Chair in Ambulatory Anesthesia and Perioperative Care and Medicine Anesthesia and Women's Health UCSF School of Medicine; Women's College Hospital; Vice Dean Staff Anesthesiologist UCSF School of Medicine Toronto Western Hospital and Women's College Hospital San Francisco, California Toronto, Ontario, Canada Joyce Chang, MD Heather A. Columbano, MD Associate Professor Assistant Professor Department of Anesthesia and Perioperative Care Department of Anesthesiology University of California, San Francisco Wake Forest Baptist Health San Francisco, California Winston-Salem, North Carolina Tyler Seth Chernin, MD Associate Professor Daniel Charles Cook, MD Department of Anesthesia and Perioperative Care Assistant Professor of Anesthesiology University of California, San Francisco Weill Cornell Medicine San Francisco, California New York, New York viii Contributors Wilson Cui, MD, PhD David Furgiuele, MD, FASA Associate Professor Assistant Professor and Associate Director of Anesthesiology Department of Anesthesia and Perioperative Care Service University of California, San Francisco New York University Langone Orthopedic Hospital San Francisco, California New York University Langone Health, Department of Anesthesiology, Perioperative Care, and Pain Ryan Paul Davis, MD Medicine Clinical Assistant Professor New York University Grossman School of Medicine Department of Anesthesiology New York, New York University of Michigan Ann Arbor, Michigan Seema Gandhi, MD Clinical Professor Andrew J. Deacon, B Biomed Sci (Hons), MBBS, Department of Anesthesia and Perioperative Care FANZCA University of California, San Francisco Staff Specialist San Francisco, California Department of Anaesthesia and Pain Medicine The Canberra Hospital Steven Gayer, MD, MBA Garran, Australia Professor of Anesthesiology and Ophthalmology Anesthesiology Anne L.
Donovan, MD University of Miami Miller School of Medicine Associate Clinical Professor Miami, Florida Department of Anesthesia and Perioperative Care Division of Critical Care Medicine Sarah Gebauer, BA, MD University of California, San Francisco Anesthesiologist San Francisco, California Elk River Anesthesia Associates; Chair, Perioperative Service Line Talmage D. Egan, BA, MD Yampa Valley Medical Center Professor and Chair Steamboat Springs, Colorado Anesthesiology University of Utah School of Medicine David B. Glick, MD, MBA Salt Lake City, Utah Professor, Section Chief, Multispecialty Adult Anesthesia John Feiner, MD Anesthesia and Critical Care Professor University of Chicago Department of Anesthesia and Perioperative Care Chicago, Illinois University of California, San Francisco San Francisco, California Erin A. Gottlieb, MD, MHCM Associate Professor Alana Flexman, MD, MBA(C), FRCPC Surgery and Perioperative Care Clinical Associate Professor The University of Texas at Austin Dell Medical School; Department of Anesthesiology, Pharmacology and Therapeutics Chief of Pediatric Cardiac Anesthesiology The University of British Columbia Dell Children’s Medical Center Vancouver, Canada Austin, Texas ix Contributors Andrew T.
Gray, MD, PhD Andrew Infosino, MD Professor Health Sciences Clinical Professor Department of Anesthesia and Perioperative Care Department of Anesthesia and Perioperative Care, University of California, San Francisco Health Sciences Clinical Professor San Francisco, California Department of Pediatrics UCSF Benioff Children's Hospital Hugh C., MD, PhD San Francisco, California Professor and Chair of Anesthesiology Professor of Pharmacology Ken B. Johnson, MD, MS Senior Associate Dean for Research Professor Weill Cornell Medicine; Department of Anesthesiology Anesthesiologist-in-Chief University of Utah NewYork-Presbyterian Hospital/Weill Cornell Medical Center Salt Lake City, Utah New York, New York Tae Kyun Kim, MD, PhD David W. Hewson, BSc (Hons), MBBS, PGCert Ed, Professor FHEA, FRCA, PhD Department of Anesthesia and Pain Medicine Consultant Anaesthetist Pusan National University Hospital Department of Anaesthesia and Critical Care Seo-gu, Busan, South Korea Nottingham University Hospitals NHS Trust; Honorary Assistant Professor Anjali Koka, MD Academic Unit of Injury, Inflammation and Recovery Science Associate in Perioperative Anesthesia University of Nottingham Department of Anesthesiology, Critical Care, and Pain Medicine Nottingham, United Kingdom Boston Children's Hospital; Instructor of Anesthesia Lindsey L. Huddleston, MD Harvard Medical School Associate Clinical Professor Boston, Massachusetts Department of Anesthesia and Perioperative Care University of California, San Francisco Benn Lancman, MBBS, MHumFac, FANZCA San Francisco, California Specialist Anaesthesiologist Department of Anaesthesia and Perioperative Medicine, Robert W.
Hurley, MD, PhD Trauma Consultant Professor of Anesthesiology, Neurobiology and Anatomy Department of Surgery Associate Dean Alfred Health; Wake Forest University School of Medicine; Specialist Anaesthetist Executive Director, Pain Shared Service Line Department of Anaesthesia, Perioperative and Pain Medicine Atrium Health—Wake Forest Baptist Peter Mac Callum Cancer Centre Winston Salem, North Carolina Melbourne, Victoria, Australia x Contributors Chanhung Z. Lee, MD, PhD Vinod Malhotra, MBBS, MD, FACA Professor Professor and Senior Executive Advisor to the Chair Department of Anesthesia and Perioperative Care Anesthesiology, University of California, San Francisco Professor of Anesthesiology in Clinical Urology San Francisco, California Urology, Weill Cornell Medicine–NewYork-Presbyterian Hospital Matthieu Legrand, MD, PhD New York, New York Professor Department of Anesthesia and Perioperative Care Solmaz Poorsattar Manuel, MD Division of Critical Care Medicine Associate Clinical Professor University of California, San Francisco Department of Anesthesia and Perioperative Care San Francisco, California University of California, San Francisco San Francisco, California Cynthia A. Lien, MD Professor and Chair of Anesthesiology Mitchell H. Marshall, MD, FASA Medical College of Wisconsin Clinical Professor Milwaukee, Wisconsin Department of Anesthesiology, Perioperative Care, and Pain Medicine Maytinee Lilaonitkul, MBBS, BSc, MRCP, FRCA New York University Grossman School of Medicine; Assistant Clinical Professor Chief of Anesthesiology Department of Anesthesia and Perioperative Care NYU Langone Orthopedic Hospital University of California, San Francisco New York, New York San Francisco, California Mary Ellen McCann, MD, MPH Linda L.
Liu, MD Senior Associate in Anaesthesia Professor Department of Anesthesiology, Critical Care, and Pain Medicine Department of Anesthesia and Perioperative Care Boston Children's Hospital; University of California, San Francisco Associate Professor of Anaesthesia San Francisco, California Department of Anaesthesia Harvard Medical School Alan J. Macfarlane, BSc (Hons), MBChB, MRCP, Boston, Massachusetts FRCA Consultant Anaesthetist Grace C. McCarthy, MD Department of Anaesthesia Assistant Professor Glasgow Royal Infirmary; Department of Anesthesiology Honorary Professor Duke University Health System; Anaesthesia, Critical Care and Pain Medicine Staff Anesthesiologist University of Glasgow Veterans Affairs Health System Glasgow, United Kingdom Durham, North Carolina xi Contributors Matthew D. McEvoy, MD Anup Pamnani, MD Professor of Anesthesiology and Surgery Assistant Professor of Anesthesiology Vanderbilt University School of Medicine; Department of Anesthesiology Vice Chair for Perioperative Medicine Weill Cornell Medical College Department of Anesthesiology New York, New York Vanderbilt University Medical Center Nashville, Tennessee Anil K.
Panigrahi, MD, PhD Clinical Associate Professor Lingzhong Meng, MD Department of Anesthesiology, Perioperative and Pain Endowed Professor and Chair Medicine and Department of Pathology Department of Anesthesiology Division of Transfusion Medicine The First Affiliated Hospital Stanford University School of Medicine Zhejiang University School of Medicine Stanford, California Hangzhou, Zhejiang, China Manuel C., MD, FASA Ronald D. Miller, MD, MS Professor and Vice Chair for Education Professor Emeritus Department of Anesthesia and Perioperative Care Department of Anesthesia and Perioperative Care University of California, San Francisco University of California, San Francisco San Francisco, California San Francisco, California Sophia P.
