Taylor Editors Salivary Bioscience Foundations of Interdisciplinary Saliva Research and Applications Salivary Bioscience www. Taylor Editors Salivary Bioscience Foundations of Interdisciplinary Saliva Research and Applications www.com Editors Douglas A. Taylor Institute for Interdisciplinary Salivary Institute for Interdisciplinary Salivary Bioscience Research Bioscience Research University of California at Irvine University of California at Irvine Irvine, CA, USA Irvine, CA, USA Johns Hopkins University Baltimore, MD, USA ISBN 978-3-030-35783-2 ISBN 978-3-030-35784-9 (eBook) https://doi.1007/978-3-030-35784-9 © Springer Nature Switzerland AG 2020 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed.
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The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG. The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland www.com Preface Thousands of investigators worldwide are actively engaged in basic, applied, and clinical research involving salivary bioscience. Our literature search reveals that across the past two decades the number of empirical papers published annually has increased substantially; in 2019 more than 1500 empirical salivary bioscience papers were published.
Investigators engaged in salivary bioscience span many academic disciplines including medicine, public health, psychology, sociology, education, neuroscience, biological science, animal behavior and welfare, infectious disease epidemiology, social neuroscience of human–animal interaction, drugs/drug abuse, social networks, nursing, psychoneuroendocrinology, anthropology, cognitive sci- ence, bioengineering, dentistry, oncology, oral health, and pediatrics. To date, the foundational information in salivary bioscience (i., 25 years of literature) is not easy or efficient to find. It is scattered across many different journals, over at least two decades, and some of the early work has been subsequently shown to be in error. This makes it challenging for new investigators interested in the topic to find the “right” information on their own.
Unfortunately, and to the best of our knowledge, there is no definitive state-of-the-art guide to interdisciplinary salivary bioscience research. Over the years there have been edited volumes from the pro- ceedings of highly specific conferences. Understandably, the nature of these pre- sentations is highly technical and narrow in scope, and the content chapters in those texts are written for an audience of highly trained experts. By contrast, this edited volume is written by leaders in multiple fields and fulfills a demand for a broad understanding of salivary bioscience across a range of disciplines.com Acknowledgements The history of the emergence of interdisciplinary salivary bioscience has been influenced by many mentors, advisors, early adopters and visionaries over many years.
Here we call attention to some of these key individuals for the significant roles they played in the development of the foundation of knowledge that scripted the “big picture”—Daniel Malamud, Lawrence Tabak, Harold Slavkin, John R. Fahey, Barbara Henker, Herbert Weiner, Dirk Hellhammer, Ben Weigand, Margaret Kemeny, Lynn Kozlowski, Elizabeth Susman, Alan Booth, James Dabbs, Jr., Peter Ellison, Lynn Vernon-Feagans, Ann Crouter, Megan Gunnar, Dante Cicchetti, Dan Leri, Clancy Blair, Martha N. Hill, Gayle Page, Deborah Gross, Robert Blum, Janet Dipietro, Tina Chang, Keith Crnic, Cary Savage, Karen Rook, Dele Ogunseitan, and Nancy Guerra. We also call attention to some of the many technical and operational experts who have made significant contributions—Najib Aziz, Eve Schwartz, Mary Curran, Skip Nelson, Laurie O’Brien, Tracy Hand, Jon Peterson, Rebecca Zavacky, Jessica Acevedo, Lillian Buitenhuys, Kelly Henning, Greg Reinhard, John Stebbins, Kaitlin Smith, Hillary Piccerillo, and Anthony Tette.com Contents Part I What Is Salivary Bioscience, Why Is It Important, and How Do We Study It? Douglas A.
Granger and Marcus K. Taylor 1 Foundations of Interdisciplinary Salivary Bioscience: An Introduction. Granger and Marcus K. Taylor 2 Salivary Gland Anatomy and Physiology.
Hernández and Marcus K. Taylor 3 Saliva Collection, Handling, Transport, and Storage: Special Considerations and Best Practices for Interdisciplinary Salivary Bioscience Research. Taylor, and Douglas A. Granger 4 Analytical Strategies and Tactics in Salivary Bioscience.
Laurent, and Crystal I. Bryce Part II Physiology and Development Research and Applications Jenna L. Riis, Section Editor 5 Salivary Bioscience, Human Stress and the Hypothalamic–Pituitary–Adrenal Axis. 89 Nina Smyth and Angela Clow 6 The Use of Saliva for Genetic and Epigenetic Research.
115 Zsofia Nemoda ix www.com x Contents 7 Saliva as a Window into the Human Oral Microbiome and Metabolome. 139 Heather Maughan and Katrine Whiteson 8 Salivaomics, Saliva-Exosomics, and Saliva Liquid Biopsy. 157 Jordan Cheng, Taichiro Nonaka, Qianlin Ye, Fang Wei, and David T. Wong 9 Salivary Bioscience, Immunity, and Inflammation.
Hernández, and Theodore F. Robles 10 Salivary Bioscience and Human Development. Hibel, Kristine Marceau, and Andrea C. Buhler-Wassmann Part III Biomedical Research and Related Applications Elizabeth A.
Thomas, Section Editor 11 Biomedical Research and Related Applications: Current Assay Methods and Quality Requirements in Oral Fluid Diagnostics Applications. Granger and Supriya Gaitonde 12 Salivary Biomarkers and Neurodegenerative Conditions. Thomas 13 The Utility of Antibodies in Saliva to Measure Pathogen Exposure and Infection. Randad, Kyla Hayford, Richard Baldwin, Lindsay Avolio, Nora Pisanic, William J.
Granger, and Christopher D. Heaney 14 Salivary Bioscience and Pain. Payne and Michelle A. Fortier 15 Salivary Bioscience and Environmental Exposure Assessment.
349 Parinya Panuwet, Priya E. Barry Ryan, and Dana Boyd Barr 16 Saliva and Drugs of Abuse. 371 Mahvash Navazesh and Azadeh Ahmadieh 17 Therapeutic Drug Monitoring in Saliva. Thomas 18 Salivary Bioscience and Periodontal Medicine.
419 Chen Xuan Wei, Yanbao Yu, Gajender Aleti, Manny Torralba, Anna Edlund, Karen E. Nelson, and Marcelo Freire www.com Contents xi 19 Salivary Bioscience and Cancer. 449 Mahvash Navazesh and Sibel Dincer Part IV Psychosocial Research and Applications Kate Ryan Kuhlman, Section Editor 20 Salivary Bioscience in Clinical Psychology and Psychiatry. 471 Kate Ryan Kuhlman, Nestor L.
Lopez-Duran, and Zahra Mousavi 21 Salivary Bioscience Research in Health Psychology and Behavioral Medicine. Hoyt and Caroline F. Zimmermann 22 The Neurobiology of Human Social Behavior: A Review of How Testosterone and Cortisol Underpin Competition and Affiliation Dynamics. Cheng and Olga Kornienko 23 Salivary Studies of the Social Neuroscience of Human–Animal Interaction.
555 Patricia Pendry and Jaymie L. Vandagriff Part V Population Health Research and Applications Marcus K. Taylor, Section Editor 24 Salivary Bioscience in Military, Space, and Operational Research. Nindl, and Brian E.
Crucian 25 Salivary Bioscience Research Related to Prenatal Adversity. 611 Shannon Shisler, Stephanie Godleski, Danielle S. Molnar, and Rina D. Eiden 26 Salivary Bioscience and Pediatrics.
Johnson and Kristin M. Voegtline 27 Use of Saliva to Better Understand the Daily Experience of Adulthood and Aging. Almeida, Jennifer Piazza, Yin Liu, and Steven H. Zarit 28 Salivary Bioscience and Research on Animal Welfare and Conservation Science.
675 Molly Staley and Lance J.com xii Contents Part VI The Way Forward: Future Directions for the Science and Practice of Salivary Bioscience Douglas A. Granger and Marcus K. Taylor 29 Applications of Salivary Bioscience to Precision Medicine. 711 Kate Ryan Kuhlman and Zahra Mousavi 30 Public Health and Industry Applications of Salivary Bioscience.
Riis, Janeta Nikolovski, Kathryn Dean Luedtke, and Diana H. Fishbein 31 Envisioning the Future of Salivary Bioscience. Zalta, and Marcus K.com Editors and Section Editors About the Editors Douglas A., is engaged in multi-institution research focused on the discovery, measurement, and application of analytes (e., enzymes, hormones, antibodies, chemicals, elements, and cytokines) in saliva. He is a Chancellor’s Professor and Director of the Institute for Interdisciplinary salivary bioscience research (IISBR) at the University of California at Irvine and holds adjunct faculty positions at Johns Hopkins University.
His studies have been instrumental in the conceptualization and analysis of biosocial relationships involving child well-being, parent–child and family relationships, as well as how these biosocial links moderate and mediate the effects of adversity and stress on health and development., is an Institute for Interdisciplinary salivary bioscience research (IISBR) Faculty Affilitate at the University of California at Irvine and a Fellow of the American College of Sports Medicine. He previously held faculty positions at Duke University and San Diego State University. His program of research focuses on stress physiology in extreme environments, blast exposure, and gene–environment interactions. His recent work appears in Journal of Special Operations Medicine, Psychoneuroendocrinology, and Psychiatry Research.
Section Editors Elizabeth A., is an Adjunct Associate Professor in the Department of Neuroscience at the Scripps Research Institute and researcher in the Department of Epidemiology and IISBR faculty affiliate at the University of California at Irvine. Her research program seeks to investigate epigenetic, biochemical, and translational biomarkers in clinical populations with neurodegenerative and/or neuropsychiatric xiii xiv Editors and Section Editors disorders. Overall, the goals of these discovery and translational research studies are to improve the diagnosis, prevention, and treatment of patients with these devastat- ing disorders., is an Assistant Professor of Psychological Science at the University of California at Irvine and member of the Institute for Interdisciplinary Salivary Bioscience Research. Her program of research focuses on the etiology of health disparities and the processes by which early-life adversity affects child development and lifelong health.
Riis’ research examines the biopsychosocial mechanisms underlying health and development from an integrated, multisystem perspective and includes studies of novel salivary markers of the immune, metabolic, and purinergic systems., conducts research on the biobehavioral processes through which adversity in childhood leads to health disparities across the life span, with a particular interest in stress-related disorders such as depression. She is currently an Assistant Professor in the Department of Psychological Science and the Institute for Interdisciplinary Salivary Bioscience at the University of California Irvine, as well as a member of the faculty in the UCLA Cousins Center for Psychoneuroimmunology. Part I What Is Salivary Bioscience, Why Is It Important, and How Do We Study It? Douglas A. Granger and Marcus K.
Taylor Chapter 1 Foundations of Interdisciplinary Salivary Bioscience: An Introduction Douglas A. Granger and Marcus K. Taylor History reveals that advances in our scientific understanding often accelerate after technological innovations improve upon our ability to observe and measure phenom- enon more precisely (e. Also, more often than not, big leaps in knowledge are the result of the collective effort of teams of collaborating investigators rather than by individual scientists working in relative isolation independently.
At least part of the argument in favor of team science is that the nature of most key phenomenon under study involves factors operating at multiple levels of analysis. Indeed, contemporary theorists assume that complex phenomenon, such as human development, disease, poverty, and public health, are determined by a confluence of effects involving interacting intrinsic individual differences, behavior, biological, and contextual factors. A major advantage of team science is that individual team members represent a deeper level of knowledge in a particular field or level of analysis than is efficient for any particular investigator to achieve and maintain. That, in theory, enables problems to be approached from dynamic inter- and trans-disciplinary In the interest of full disclosure, Douglas A.